الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 205 |  |  |
| | | from | 205 | | |
Abstract
There are few studies dealing with chronic villus sampling and similar technique in Egypt This has prompted us to study the potentiality of using chronic villus sampling technique as a method of prenatal diagnosis of chromosomal abnormalities for high-risk couples Fifty women were recruited from among the attendants of the Antenatal Clinic of El Minia University Hospital to undergo chronic villus sampling, Maternal age was close to or greater than 35 years, The indications for chronic villus sampling in those women were maternal age greater than 35 years ( 35 cases ), previous child with Downs syndrome ( 5 cases)`:and 10 cases for Miscellaneous Conditions, Including past or family history of mental Retardation, Pregnancy on top of Intrauterine Contraceptive device and Drug Exposure.
The Procedure was not attempted and Cancelled in 5 of these Patients because fetal viability was not confirmed in one patient, vaginal bleeding in two patients; the gestational age was more than 14 weeks in one patient and the fifth patient was carrying a twin this study included six stages.
These are history, examination, ultrasonography, sampling, analysis and follow up.
In this study procedure was done under local anesthesia for all the patients. Maxwell et al (1986)used general anesthesia for all patients, but subsequent experience by lilford(1987) and hogdall (1988) suggests that this procedure can be carried out under local anesthesia with no more discomfort than amniocentesis and less pain than with the transcervical method. Now this procedure can be carried out without administration of anesthetics (Brambati et al. 1987).
In this study several different needles were tried and evaluated. L found that the 19 gauge spinal needle produced the best result with adequate samples of tissue for karyotyping. When the guide needle was in place the aspiration needle could be moved up and down without causing discomfort to the patient and two to three aspirates could be done to obtain the required amount of tissue.