الفهرس 
INTRODUCTION AND AIM OF THE WORKOnly 14 pages are availabe for public view
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Abstract
Aim of the work
To test the hypothesis that oxygen free radicals are mediators of excessive protein permeability in the nephrotic syndrome.
Conclusion
We concluded that antioxidants level and the oxidation by products concentrations varies with different stages (acute and remission phases) and different types of NS (steroid responsive and resistant NS), and that lipid peroxidation may plays a major role in the production of proteinuria in the first attack or in the relapse of the disease, and in the pathogeneses of nephrotic syndrome also, NO may play a protective role in nephrotic syndrome as indicated by its high level of NO in the acute phase of SSNS.
The continuous production of NO in the remission phase may serve to scavenge small fluxes of superoxide radical produced by endothelial cells. Copper, zinc and selenium concentrations decreased in the remission phase and this may indicates loss in urine and its use in neutralization of oxidative stress.
Increased concentration of G6PD in steroid unresponsive nephrotic patients and in relapsing nephrotic syndrome may indicate a more oxidative stress in those patients than patients with SSNS or those with first attack.