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Abstract Aim of the work Is to delineate the effect of zinc supplementation in diarrheal diseases both acute and chronic with estimation of serum zinc level before and after therapy. Conclusion In conclusion: the significantly higher serum zinc level in cases of acute diarrhea could be explained by the presence of dehydration (mild and moderate) and the explanation for the low serum zinc level after supplementation in both acute and chronic diarrhea may either due to the insufficient dose of zinc given or due to the shorter duration of therapy or due to the unsuitable route of administration. This point needs a further study on a wider scale in order to be clarified. We may suggest that zinc supplementation to be effective in chronic diarrhea should be used with larger dose and longer duration than that used for acute diarrhea and taking in consideration the route of administration. |