الفهرس 
Introduction and Aim of The WorkOnly 14 pages are availabe for public view
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Abstract
Aim of the work
To evaluate plasma thrombomodulin level in newborn infants with RDS.
Summary and conclusion
This study was carried out 40 neonates with RDS. Twenty of them were preterm and the rest were full term. Another 30 cases were taken as controls, fifteen of them were preterm and the rest were full term.
All cases and control subjects were subjected to through history taking, through clinical examination, chest X-ray and laboratory investigations.
Laboratory investigations included complete blood count, serum creatinine and plasma thrombomodulin evaluation.
Infants with RDS showed higher significant levels of thrombomodulin P<0.05. They had normal levels of creatinine and normal CBC values.
Thirteen infants with RDS had asphyxia. They showed higher significant thrombomodulin level than cases without asphyxia (P<0.05).
Seven cases died. There was no significant difference in plasma thrombomodulin level between them and survivors.
There was negative correlation between Apgar scores in both at 1 and 5 minutes and thrombomodulin levels. Also there was negative correlation between platelet count and thrombomodulin level.
We could conclude that thrombomodulin level increases in infants with RDS due to excessive production of thrombomodulin due to endothelial injury. Endothelial injury in RDS may be due to hypoxia or pre-DIC state.