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Abstract The work described in this thesis is concerned with the application of the reaction established by J.M. Tedder in 1957 which deals with the direct introduction of diazoonium group in aromatic nuclei. Tedder applied this reaction to some activated aromatic compounds and to a limited number of hetercyclic derivatives containing one or two hetero atoms of one type. Chapter I is a complete survey of the interaction of nitrous acid with aromatic compounds in the presence of excess sodium nitrite. It cover the decomposition of diazonium fluoroborates to give the corresponding fluorine organic compounds. Chapter II is concerned with the theoritical discussion for the work originated in this thesis and falls in two direction : First: The interaction of antipyrine with nitrous acid in the presence of excess sodium nitrite followed by the addition of fluoroboric acid and this resulted in the formation of antipyrine-4’-diazonium fluoroborate which on pyrolysis gives 4~fluoroantipyrine. |