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Abstract
Key words : Alloxan, polyunsaturated fatty acids- liver & kidney fmetion , lipid profile. – Hypoglycemia.The effect of administrating diets containing different oil blends rich in long chain polyunsaturated fatty acids (LC – PUFA) on body weight gain, organs weight, liver enzymes (ALT & AST); lipid profile (Total cholesterol; High density lipoprotein (HDL – ch), low density lipoprotein, (LDL – ch), Triglycerides, and risk ratio); kidney function (B.Urea,Uric Acid and S.creatinine), total protein, albumin globulin and blood sugar were studied in the experimental Albino rats. The feeding experiment was carried out during six weeks after adaptation period which was prolonged for two weeks. The results were compared with control group of rats fed a balanced diet (Negative control) and alloxan diabetic rats (Positive group) . The results showed that a single dose of alloxan injection (150 mg /Kg body weight) produced hyperglycemia, elevated total cholesterol, LDL, and risk ratio. Moreover, Kidney function and liver function were elevated. Also, body weight gain, organs weight and HDL.C were decreased. Administrating diets containing oil blends consisting of soy oil (SYO) and flaxseed oil (FLO) which were prepared as follow: the first blend was a mixture of FLO : SYO (10 : 90, w/w), the second mixture of FLO : SYO (20 : 80, w/w) and the third mixture of FLO : SYO (40 : 60, w.w.)All studied oil blends confirmed the efficacy of such blends in the modulation of the oxidative stress associated with diabetes mellitus in different order. We could suggested that, oil blends rich in LC- PUFA could be used as antidiabetic complement in case of DM. This may be related to its anti oxidative properties.