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Abstract
Hiipatocelhibi carcinoma (HCC) is one of the coimnonest malignancies
worldwide and its incidence is increasing. Treatment including curative resection. ablation or liver transplantation is possible if the tumour is detected at an early stage. Current diagnostic tests have a poor sensitivity and specificity, Unfortunately, even with the recent imaging techniques. early diagnosis oih small minors is often difficult particularly on the background of cirrhosis.
”I he overall aims of (his thesis were to evaluate the staging systems in predicting survival in Egyptian patients with HCC and to identify potential early disease markers using MRS for metabolic profiling of urine in patients with HCC.
The initial study included H52 patients diadnosed with UCC in the cancer clink;,
National Liver Institute, Menoufiya University.
All patients were subjected to through medical history taking, complete clinical
examination, liver function tests* AFP testing, abdominal US. triphasic CT, chest
x-ray.
The results revealed that CLIP scoring system was The best iu discriminating
survival in patients presented with late stage HCC while, BCLC was the best for
patients with early stage HCC. DC’I.C has the advantage of olterjng treatment to
these paiknls. Hence, the need for new biological biomarkers 10 delect (he disease
curly and improve survival.
Magnetic ce so nance spectroscopy (MRS) of body fluids can characterise metabolic changes within the main cellular pathways in disease ;ind can potentially identify biomarkecs ofdiseasc progression to HCC. .M) pal isms were enrclled in the study classified into 3 groups. Group 1 included ’ patients with I ICC; group 2 included 20 patients v\iih liver cirrhosis while group 3 included 13 patiems with chronic HCV infection; in adition to 17 healthy subjects as a healthy controls. All patients participating in the study were asked lo provide a urine sample which is subjected to H1 MRS. Metabolic profiling of urine