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Abstract
Epilepsy is one of the most common neurologic disorders of the
brain. The currently available antiepileptic agents do not provide
adequate control of the disease in all epileptic patients. In the present
study, repeated administration of pentylenetetrazole (PTZ) in rats
produced kindling. In addition, PTZ-kindled group showed elevated
plasma lipid peroxides levels and increased glutathione peroxidase and
catalase activities. whereas, superoxide dismutase activity did not
change from the normal value. Both of the antioxidants, coenzyme QlO
and lipoic acid, and nifedipine per se demonstrated some protection
against PTZ kindling. The biochemical analysis of oxidative stress
markers came in line with the behavioral effects of the different drugs.
It is concluded that nifedipine, coenzyme QIO, and lipoic acid may
have important potentials as adjunct medications with some antiepileptic
drugs.
Key words: Epilepsy, Pentylenetetrazole, Kindling, Diazepam, Phenytoin