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Abstract Bacterial causes of fin rot disease m fresh water fishes had been carried out on species of Tilapia nilotica, Clarias lazera and Common carp which collected from the ponds of central lab. for aquaculture Research of Abbassa, Ismailia Canal and its tributaries. It was designed to include: 1- Isolation and identification of the most common bacterial pathogens from diseased fishes, naturally infected with fin rot. 2- The pathogenicity of the isolated bacterial pathogens in Armout catfish by different methods. 3- Application of the antibiotic sensitivity test on the isolated bacteria as a mean for the control of such pathogens. Investigation of the histopathological alterations in different organs of the experimentally infected fish. The results of these studies were summarized as follow: The clinical examination of 90 naturally infected Tilapia species, 50 Clarias species and 30 Common carp with fin rot revealed progressive erosions, congestion and haemorrhages of the body fins especially the caudal and dorsal fins with oedema and sloughing in some cases. The postmortem changes of naturally infected fishes were abdominal ascitis, enlargement and congestion of the liver, kidneys, spleen and |