الفهرس 
Introduction & aim of the work
Diabetes MellitusOnly 14 pages are availabe for public view
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Abstract
Summary and Conclusions
Diabetes is a chronic disease and cardiovascular morbidity is very high among individuals with diabetes and atherosclerosis is a progressive change with its roots in childhood.
This study investigated the vascular intimal medial thickness changes of both common carotid arteries to show subclinical atherosclerosis using B-mode high resolution ultrasound.
Twenty-five children with type-1 diabetes aged 4 to 16 years (mean 11.3±SD 3.1) 13 females and 12 males were selected from out patient diabetes clinic, fulfilling the inclusion criteria designed for the study. Twenty apparently healthy children were selected as a control group; the 2 groups were matched for age, sex and BMI.
Patients and control were subjected to full clinical examination including blood pressure, BMI, and WHR and tested for lipid profile; HbA1c and microalbuminuria done for 10 diabetic patients only. Right and left CIMT were assessed by high resolution B-mode ultrasound.
In the present study, CIMT on both sides were significantly greater in type-1 diabetic children when compared to the healthy controls.
In addition, both CIMT showed a statistically significant positive correlation with age and duration of diabetes.
LCCA-IMT showed a statistically significant positive correlation with BMI, DBP, LDL, TG and HbA1c and negative correlation with HDL (protective).
RCCA-IMT showed a statistically significant positive correlation with daily insulin dose.
Conclusions
From the present study we concluded that CIMT is increased in children with type-1 diabetes compared with normal non diabetic children. CIMT positively correlates with age, duration of diabetes, BMI, DBP, LDL, TG, HbA1c as well as daily insulin dose and correlates negatively with HDL.
Thus the assessment of the CIMT is a non invasive method and easy to perform and its measurement may provide complimentary information especially about the structural status of the vascular system in diabetic children at increased risk for cardiovascular complications even in the absence of clinically apparent macrovascular manifestations.