الفهرس | Only 14 pages are availabe for public view |
Abstract Aim of the work To compare serum concentrations of thyroid hormones, T3, T4, and thyroid stimulating hormone (TSH) found in the umbilical cord blood of term newborns with and without asphyxia and those found in their blood collected between 18 and 24h after birth. Conclusion The results of this study showed that the hormonal levels of T3, T4 and TSH were the same in the cord blood in both asphyxiated and control groups, but hormonal levels in the asphyxiated group were lower than that of the control group and that of the cord blood in the samples taken to 18 to 24 hours after birth. The pattern of alterations of the hormonal levels found in the arterial blood of the asphyxiated newborns suggests the occurrence of central hypothyroidism, in which low levels of thyroid hormones are secondary to low concentrations of TSH. Studies that evaluate the role of T3, T4 and TSH restoration in patients with subnormal hormonal levels should also be considered. The importance of the thyroid hormones to the normal development of the brain and the intellectual functions and their relation with patient’s prognosis requires follow-up studies that correlate hormonal alterations with the occurrence of neurological sequalae. |