الفهرس 
Material and methodsOnly 14 pages are availabe for public view
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Abstract
SUMMARY AND CONCLUSION
SUMMARY AND CONCLUSION
This work was conducted to study the significance of neutrophil
count and functions in patients with unstable angina and its correlations
with left ventricular function.
This study included 35 patients admitted to coronary care unit and
diagnosed as unstable angina, 10 patients with stable angina, and 10
healthy controls. All were subjected to the following:
(1) Full history taking.
(2) Clinical examination and assessment.
(3) ECG.
(4) Serum CPK to rule out AMI.
(5) Echo Doppler to assess LVEF% and wall motion abnormalities.
(6) Chest x-ray P. A view.
(7) Coronary angiography to assess the site and degree of coronay
artery lesion.
(8) Laboratory assessment of neutrophil count and functions including
the following:
(i) WBCs count.
(ii) Assessment of chemactactic function of neutrophil using
under agarose method .
(iii) Assessment of intracellular killing activity using nitroblue
tetrazolium test.
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SUMMARY AND CONCLUSION
(iv) Assessment of ingestion and phagocytic power of neutrophil
using leucotriene by (LTB4).
All samples were obtained by venipuncture 24-72 hours after onset of
last attack of chest pain. The patients were followed up for 6 month after
discharge from hospital by clinical examination and echocardiography.
Patients were classified into those with complications and without
complication and on the other hand to dead and living cases.
Thefollowing results were obtained:
There was significant increase in WBCs count in unstable angina
patients in comparison to stable angina and control groups.
Phagocytic function and intracellular activity were significantly higher
in stable angina group than in unstable and control groups while, there was
no significant difference between unstable and control groups.
Chemotactic function was significantly higher in stable group than in
other groups.
There was no significant difference between the 3 different groups of
unstable angina (crescendo, Resting and post infarction) as regards
neutrophil count and functions .
On comparing complicated & non complicated cases the following
results were obtained :
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SUMMARY AND CONCLUSION
There was significant increase in WBCs count in complicated cases
also>LVEF% was significantly lower in complicated cases, three vessel
disease was significantly more prevalent in complicated cases. While,
There was no significant difference between both groups as regards age,
sex, risk factors, ECG as well as nutrophil functions.
There was a significant increase in WBCs count in patients who died
than in living cases, also LVEF% was significantly lower in dead cases,
also three vessel disease was significantly more prevalent in this group of
patients. While, there was no significant difference between both groups as
regard age, sex, risk factors as well as neutrophil functions.
In patients with unstable angina, there was significant negative
correlation between WBCs and LVEF% on admission to hospital as well
as after 6 months follow-up. On the other hand, there was insignificant
correlation between neutrophil functions and LVEF%.
It is concluded from the present study that the best predictors of
complications occurrence were WBCs count and LVEF%.
Multivariant analysis clearly showed that WBCs count , number of
coronary vessels diseased by coronary angiography and LVEF% were
independent predictors of complications after hospital discharge.
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