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Abstract Animal parasitic diseases caused by helminth infestation have been recognized as a major problem facing the human health and animal production in Egypt. These problems are due to the parasitic helminths which absorb the host food, suck the host blood, and damage the host tissues. Worms pathogenic for animal and human being are metazoa conventionally classified into nematodes, trematodes, and cestodes. This biological diverse vary with respect to life cycle, structure, development, physiology, localization within the host, and susceptibility to chemotherapy. Chemicals that can be used to remove endoparsites without undesirable side-effects on host animals or man are difficult to discover and develop (Prichard, 1990). Various compounds have been used since the beginning of this century, in an attempt to control helminth parasites. The limited antiparasite efficacy and the large number of side-effects were among the main limitations o,f earlier compounds (Lanusse and Prichard, 1993). Desirable features for an ideal anthelmintiC drug are: (a) broad-spectrum activity at a reasonably inexpensive and safe dosage rate; (b) easy and practical administration; (c) low drug residues, which allow short withdrawal periods before treated animals could be used for human consumption |