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Abstract
Sodium valproate is a broad-spectrum antiepileptic used in the management of epileptic seizures in children. The present study was conducted on 20 epileptic children on sodium valproate therapy for more than 6 months to assess carnitine status in those patients. Ten children with matched age and sex were taken as control before starting treatment
All was subjected to
• Thorough history taking
• Detailed clinical examination
• Assessment of nutritional status
• Routine standard EEG
• Laboratory investigations
o Total serum carnitine level
o Trough sodium valproate blood level
o Liver function tests
o Serum creatine phosphokinase
• Needle electromyography of gluteus medius tibialis anterior deltoid and 1st dorsal interosseous muscles
From the result of the study it can be said that the serum l-carnitine level was significantly lower in children with epilepsy on valproate monotherapy or polytherapy than the control group. The serum l-carnitine level was lower among the group on polytherapy than on monotherapy. There is a correlation between liver enzymes, serum creatine phosphokinase level and serum l-carnitine level. All children with epilepsy treated with anticonvulsants showed myopathic changes.