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Abstract BACK GROUND: A controlled randomized trial is carried out on thirty female patients suffering from operable breast cancer ( stage I & II ); patients were divided into two groups: OBJECTIVES: Comparative Study Between Methylene Blue And Isosulfan Blue Dye For Detection Of Sentinel lymph Node In Operable Breast Carcinoma METHODS: A controlled randomized trial is carried out on thirty female patients suffering from operable breast cancer ( stage I & II ); patients were divided into two groups: Group I : Fifteen patients were injected by methylene blue dye at the subareolar region . Group II : Fifteen patients were injected by patent blue dye at the subareolar region . All patients were subjected to: Full history taking . Meticulous clinical examination, including both axillae for any clinicaly palapable lymph nodes. Routine laboratory investigations . Mammogaphy Abdominal ultrasongraphy RESULTS: The age distribution in the present series ranged between 24 and 65 years with a mean of 45.2 years. The commonest affected site was the upper outer quadrant (53.4%). The tumor size varied between 0.5 and less than 5 cm in its greatest dimension. 29.4% of patients with palpable movable axillary nodes proved to be node negative following ALND and 15.4% of clinically node negative patients had metastatic nodal involvement. SLN was successfully idenfied in 93.3% of cases. SLN identification rate in group I (methylene blue injection) was 93.3%. SLN idenitification rate in group II (patent blue injection) was 93.3%. SLN was commonly located at level I (92.85%). Skip metastasis was found in 7.15% of cases. CONCLUSIONS: The sensitivity of lymphatic mapping in the study was 100%. The positive SLN predicted the positive axillary basin in 100% cases, also negative SLN predicted the negative axillary basin in 100% of cases. |