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Abstract
Stress is associated with the development of numerous diseases, such as gastric ulcer, cardiovascular diseases, cancer, immune system diseases , renal disorders ,respiratory diseases and psychological disorders. The present study was carried out to investigate the pathophysiological changes in male albino rats through the exposure of rats to sound stress for 10 minutes per hour for 3 month. The following parameters were determined; serum glucose level, serum lipid profile, insulin, corticosterone glutathione, glutathione peroxidase, superoxide dismutase , and glucose utilization . The present study was carried out in a trial to provide an approach about the effect of sound stress on diabetes mellitus.
The obtained results can be summarized as follows:-
I- Effect of sound stress on normal male rats.
a- Stress produced non significant changes in serum glucose, insulin, the area under glucose ,HDL, GSH and GSH px levels .
b- Stress significantly decreased cholesterol , LDL and corticosterone serum levels.
c- Stress significantly elevated serum triglyceride and superoxide dismutase level.
II –Effect of sound stress on STZ induced diabetes mellitus in rats:-
A – Effect of STZ in different dose levels (25, 30 and 38 mg/kg) of stressed rats:
1- Stressed rats injected with STZ in a dose 38mg/kgshowed a significant decrease in serum glucose level and the area under the glucose curve.
2- Stressed rats injected with STZ in doses 25, 30 and 38mg/kg each in a separate group showed a significant decrease in serum cholesterol and LDL levels.
3- Stressed rats injected with STZ in doses 25 and 30 mg/kg showed a significant increase in serum triglyceride and HDL levels.
4- Stressed rats injected with STZ in doses 25 and 30 mg/kg showed a significant increase in GSH px levels.
5- Stressed rats injected with STZ in doses 25, 30 and 38 mg/kg showed a significant increase in SOD levels.
6- Stressed rats injected with STZ in doses 30 and 38 mg/kg showed a significant decrease in serum corticosterone levels.