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Abstract Foot-and-mouth disease virus is the causitive agent of an acute and highly contagious febrile vesicular disease affecting cloven-footed animals. It is considered to be the most economically important disease affecting wild and domesticated animals. Identification of FMDV posed problems because of the occurrence of seven serotypes, A, 0, C, SATl, SAT2, SAT3 and ASIAl, and many subtypes of the virus. Even though disease caused by different serotypes can be indistinguishable clinically there is little to no cross-protection, as animals infected with one serotype still remain fully susceptible to infection with other serotypes , The vaccination program against the FMDV serotype ”0”, the most predominant serotype in Egypt, is applied on animals in Sharkia Province in 2006 however a severe outbreak of FMD occur within different localities therefore, the present study was submitted to carryout a comparative seroprevalence of different FMDV serotypes’ specific antibodies among animals in Sharkia Province using solid phase blocking ELISA and the isolation of the local FMDV serotypes on BHK cells with their identification molecularly using RT -PCR. |