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Abstract The present study was carried out to evaluate the genetic differences among three breed of rabbit (Egyptian Baladi, New Zealand White and Californian ) and their different receprocal two--breed crosses in huineral immune response to Pasteurella multocida ( hemorrhagic septicemia vaccine and Sheep red blood cells as well as the cell mediated immune response to Bacillus Calmette Geurin. The animal used in this study were part of research flock belonging to Animal husbandry Department, Faculty of vetrinary medicine, Alixandria university. Male end female rabbits of Egyptian balady, New Zealand White and Californian breeds were mated in a complete three— breed diallel crossing design to produce all different purebred and crossbred progenies. The results obtained can be summarized as the following: 1— Pasteurella multocida vaccine antibody titer was not significantly affected by any of the factors studied including male line, female line, sex, breed and the interactions between them. New Zealand White x Californian and Ba•ladi x New Zealand White crossbred rabbits had the highest immune response titer to Pasteurella mutocida |