الفهرس 
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Abstract
Coronary heart disease (CHD) is the primary cause of premature mortality in most modern societies. In transitional or modernizing societies, such as the countries of Eastern Europe and Asia, the rate of CHD mortality is increasing Cardiovascular disease are responsible for about 50% of total mortality in Germany.Atherosclerosis is the pathologic condition underlying myocardial infarction and other acute coronary syndrome, which are among the leading cause of morbidity, mortality and health care expenditure in adults.Some of risk factors, or characteristics associated with an increased chance of developing coronary illness, include age, sex, arterial hypertension, high level of serum cholesterol, triglycerides (TG), and an unfavorable serum lipid profile (high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) .The importance of TG in the development of atherosclerosis is currently receiving increasing attention in view of growing evidence that constitute as independent risk factor for cardiovascular disease. Cholesterol level has been estimated in different fractions of lipoproteins and has been approved as independent risk factor for the development of CHD.Growing evidence indicates that chronic and acute overproduction of reactive oxygen species (ROS) under pathophysiologic conditions is integral in the development of cardiovascular disease (CVD). Reactive oxygen species mediate various signaling pathways that underlie vascular inflammation in atherogenesis: from the initiation of fatty streak development through lesion progress to ultimate plaque rupture. Human investigations also support the oxidative stress hypothesis of atherosclerosis. Oxidative stress is the unifying mechanism for many CVD risk factors, which additionally supports its central role in CVD. Liquid peroxidation is a well known example of oxidative stress damage in cell membrane, lipoproteins and other lipid containing structures. Erythrocyte membranes are liable to lipid peroxidation owing to their content of polyunsaturated fatty acids (PUFAs) and to the fact that they are directly exposed to molecular oxygen.The biochemical defense that protect organism from the free radical damage includes both low molecular weight free radical scavengers as vitamin E (Vit E), Vit C and complex antioxidant enzymatic system including superoxide dismutase (SOD), glutathione peroxidase (GSH-PX) and catalase (CAT).Omega-3 (n-3) fatty acids from fish oils can protect against CHD. Both health professionals and the public are increasingly interested in their role in the prevention and management of CHD. The relation between n-3 acids and cardiovascular disease was established following the observation that the Greenland Eskimos had low mortality from CHD despite a diet that is rich in fat