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Abstract
The present investigations were performed on two hundred chickens,
which classified into ten equal groups. The 1 S\ 2nd, 3rd, 4th and 5th groups were used as experimental control. other groups were vaccinated with imported bacterin (gps 7 and 8) and autogenous bacterin (gps 9 and 10 ) then challenged with virulent HPG strain chickens of gp 6 were infected with virulent HPG. The clinical signs of chickens which had been vaccinated with imported vaccine were slight nasal discharges in the chickens (gps 2 and 3), with slightly congested nasal cavity and sinuses. Microscopically hyperplasia of epithelial
lining with metaplasia into goblet cells and lymphocytic infiltrations were seen. The chickens which had been vaccinated with imported vaccine then
challenged with HPG (gps 7 and 8) showed nasal discharge and swollen face
and unilateral mild swelling of infraorbital sinuses, in addition to mortality rate (5%) after their challenge in chickens received single dose, while double doses of vaccine gave good protection (100%).
The chickens vaccinated with commercial autogenous bacterin (gps 4and 5)
revealed neither clinical signs nor post mortem lesions.The chickens vaccinated with commercial autogenous bacterin and had been challenged with virulent HPG strain (gps 9, 10) showed no clinical signs, no mortality after their challenging and 1000/0 protection, with mild pathological
findings reflected normal body reaction, including lymphocytic aggregations and proliferative glands in the mucosa and submucosa of nasal sinuses, larynx and trachea, beside severely enlarged lymphoid follicles were also detected. Lungs showed hyperplastic parabronchial aggregations. Liver showed
lymphocytosis and heterophilia in some portal blood vessels, the latter was
represented by numerous lymphocytes or heterophils in the lumina of the
affected blood vessels