الفهرس 
REVIEW OF LITERATUREOnly 14 pages are availabe for public view
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Abstract
This study included 50 patients with hepatocellular carcinoma. The results revealed that p53 inactivation (mutation) may be involved in the molecular pathogenesis of HCC, p53 mutations were late events in HCC and their frequency was associated with tumor progression and mdm2 over expression may also be involved in the molecular pathogenesis of HCC. Tumors with mdm2 over expression were devoid of p53 mutations and vice versa indicating that they represented alternative mechanisms for inactivating the same regulatory pathway for suppressing cell growth.