الفهرس | Only 14 pages are availabe for public view |
Abstract I vermectin (a mixture of 22, 23 dihydroavermectin B 1 a with minor amounts of 22, 23 dihydroavermctin BIb) is one of the most successful veterinary antipariasitic drugs. It has parasitocidic activity and is used as the main substances of insectoacaronematocids. In humans I vermectin is the drug of choice for the treatment of onchocerciasis (African fever blinders and lymphatic filariasis). Clorsulon (Clorsulon has a chemical structure of 4-amino- 6- trichloroethenyl- 1.3- benzenedi-Sulfonamide), It is the most Potent fashiolicide drug. This work was conducted to evaluate the possible effect of the two drugs, given either singly or in combination on developing rat foeti. The effect of therapeutic dose of Ivermectin and/or Clorsulon on reproductive efficiency of female rats: Seventy mature pregnant rats were divided into seven groups each of ten animals. The first group was used as control. The second group was subcutaneously injected with therapeutic dose of ivermectin 0.2mg/200 gm B.wt. on the 6th day of gestation, the third group was subcutaneously injected ~ith the same dose of clorsulon 0.2mg/200 gm B.wt. on 6th day of gestation., the fourth group was injected subcutaneously with therapeutic dose of (Ivrmectin/ Clorsulon) 0.2mg/ 200 gm B.wt. on the 6th day of gestation. The fifth group was injected subcutaneously with therapeutic dose of Ivermectin 0.2/200 gm Bwt. on the lOth day of gestation., the sixth group was injected subcutaneously with therapeutic dose of clorsulon 0.2mg/ 200 gm B. wt on the lOth day of |