الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
 |  | from | 256 |  |  |
| | | from | 256 | | |
المستخلص
The present study aimed at screening the efficacy of Apium graveolens (A. graveolens) methanolic seeds and aqueous leaves extracts on liver damage induced by carbon tetrachloride (CCL4), compared with a standard silymarin as a settled anti-hepatotoxic agent. In addition to focus a spotlight on the prophylactic and therapeutic treatment efficacy of A. graveolens seeds and leaves extracts. The study was performed on 25 groups of albino rats, in which three experiments : pilot which divided into 2 preliminary experiment, the first (3 groups) and the second (4 groups), pretreatment CCL4 (9 . groups) and post-treatment CCL4 (9 groups) were done.
Our results were summarized into the following: Pilot experiment: -
A ] CCl4 induced hepatotoxicity :
Carbon tetrachloride (CC4) diluted in olive oil (1 : 1 V/V) was
injected intraperitoneally (LP.) at a single dose of 1 ml/kg B.wt. to one
group of albino rats and 2 ml/kg B.wt. to. another group. The levels of
serum AL T & AST were estimated in the two tested groups to reflect the
degree of liver intoxication induced by CC4 . It was found that 2 ml /kg
B.wt. CC4 induced acute hepatitis than 1 ml/kg B.wt. CCk Blood
samples were collected 48 hs. After CC4 intoxication. B ] Anti-hepatotoxic effect of Apium graveolens seeds extract: One group of albino rats was injected intraperitoneally with CC4
(2 ml /kg B.wt. in olive oil) at the first day of the experiment followed