الفهرس 
Introduction and Aim of workOnly 14 pages are availabe for public view
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Abstract
The results obtained in the present study clearly demonstrate that : -
- Ovariectomy results in a significant reduction in BMD, dry weight, ash content, femoral calcium content and organic matrix weight of left femurs compared to the control group, indicating that there was a decrease in bone mass rather than a decrease in bone mineral.
- The ovariectomized group showed the lowest bone density between all groups compared with the control group. Ovariectomy resulted in 15.5% decrease in BMD of the left femurs.
- The results obtained in the present study demonstrated that serum calcium concentration did not show any significant change following ovariectomy. This could be explained by the fact that homeostatic mechanisms were able to maintain serum calcium level for eight weeks despite ovariectomy
- Serum calcitonin level decreased after ovariectomy and increased with estrogen supplementation
- The combination groups which were supplemented with (estrogen and progesterone) and (calcitonin and calcium) increased BMD, dry weight, ash content, organic matrix weight and ash calcium content of left femurs. The percentage changes in BMD were 18% and 17.3% in these groups respectively as compared to the ovariectomized group.
The highest increase in BMD was observed among the combination groups which were supplemented with (estrogen and progesterone) and (calcitonin and calcium) with insignificant differences between them. This may suggest that the antiresorptive action of estrogen and progesterone could be mediated apart by an increase in calcitonin levels.
- Estrogen and progesterone together gave complete improvement in BMD but either estrogen or progesterone therapy alone gave a partial improvement.
- Calcitonin decreased serum calcium level, increased partially BMD and increased significantly bone dry weight, organic matrix weight, ash content and ash calcium of left femurs compared to OVX group.
- The calcium supplemented ovariectomized group had insignificant difference with the ovariectomized group in all femur parameters.