الفهرس 
AcknowledgmentOnly 14 pages are availabe for public view
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Abstract
Schistosomiasis is one of the major health problems in many developing countries. In Egypt, it heads the list of endemic parasitic diseases with regard to prevalence, gravity and morbidity. Compounds of various classes were established as effective schistosomicides in order to control this serious infection. This study was planned to investigate the effect of some of these drugs on the terminal oxidase. cytochrome P—450, its associated flavoprotein, NADPH—cytochrome c reductase, and the microsomal P—450-dependent aryl hydrocarbon hydroxylase. These enzymes are responsible for the oxidative detoxification of xenobiotics. However, substrate oxida¬tions catalyzed by these enzymes frequently have the undersired consequence of leading to highly reative metabolites responsible for cellular toxicity, mutagenicity and carcinogenicity.
\ The data< obtained from this study showed that oxamni— quine and niridazole markedly increased the amount of cytochrome P-450 of the mouse hepatic microsomes following repeated dose administration for three consecutive daysT] Conversely, hycanthone inhibited the amount of hepatic P-450 following both single and repeated dose treatments. whereas praziquantel inhibited the cytochrome P-450 content significantly after single dose treatment only. Metrifonate and the antimonial drugs, anthiomaline and astiban, did not alter the amount of P-450 to any extend.