الفهرس Only 14 pages are availabe for public view
 |  | from | 87 |  |  |
| | | from | 87 | | |
Abstract
Background: Skin tags are common benign skin tumours usually occurring on the neck and major flexors of elder people. Skin tags are histologically composed of loose collagen fibers and dilated capillaries enclosed in a hyperplastic epidermis. Objectives: The aim of this study is to perform quantitation of mast cells and collagen fibers in skin tags and normal skin in diabetics and non diabetics, in order to find the the possible correlation between mast cells and collagen fibers in the pathogenesis of skin tags. Participants and Methods: Thirty participants with skin tags were divided into two groups (15 diabetic and 15 non diabetic).3 biopsies were obtained from each one : a large skin tag, a small skin tag and adjacent normal skin. Mast cell count was done in 10 fields and the average count was correlated with mean collagen area % in 5 fields done by the Image analyzer. Results: A statistically significant correlation between mast cell count and collagen mean area % was detected in both studied groups ( except in large lesions of the non diabetic group, but it was near to be significant ;Pvalue = 0.052). In our study mast cell count in skin tags and normal control was statistically higher in the diabetics than the non diabetics. Conclusion: Both mast cell mediators and hyperinsulinaemia are involved in the pathogenesis of skin tags.