الفهرس 
ContentsOnly 14 pages are availabe for public view
 |  | from | 340 |  |  |
| | | from | 340 | | |
Abstract
Carcinoma of the urinary bladder is the most common malignancy in many tropical subtropical countries. There is a well documented sequela of chronic urinary listosomal infection and bladder cancer associated with schistosomiasis is a major cause [morbidity and mortality in the endemic areas. Experimental bladder cancer can be induced schistosome-infected animals. Multiple factors have been suggested as causative agents tschistosome-associated bladder carcinogenesis and the W-nitroso compounds appear to be |particular importance. These agents have long been suspected to play a major role in the piology of variety of human cancers. The induction of bladder cancer associated with jsomiasis has been studied taking into account the interrelationships between different ; resulting from the infection, especially the role of alkylating agents that can contribute induction of this neoplasm.
Male Balb/c mice were infected with the carcariae larvae of Schistosoma mansoni pretreated (i.p.) with W-nitrosodimethylamine (NDMA) at 20 mg/kg for 1 hour prior ipling. Livers were taken for analyses at 15, 30 and 45 days post-infection. By rison with age matched controls, changes were observed in liver weight, hepatic lal protein and enzymes of xenobiotic metabolism. Transitory increases in the of NDMA demethylase-1 and to a greater extent of arylhydrocarbon hydroxylase Sjnansoni infection and/or NDMA pretreatment indicate an increased capacity to active metabolites potentially capable of acting as initiating agents in the period ling infection. Increased glutathione levels over a similar time course may partly for these effects. These observations indicate that schistosome infection could the deleterious effects of environmental carcinogens such as N-nitrosocompounds