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Abstract
Systemic lupus erythematosus (SLE), the prototype of systemic autoimmunity, affects the quality of life and often result in irreversible organ damage and early death (Ziakas et al., 2006).
A Number of efforts have been undertaken lately to associate certaine epidemiological, clinical characteristic and therapeutic intervention to irreversible organ damage and early demise. Among them increased age and disease duration. CNS, renal disease and high dose chorticosteroid seem the most influential damage is also independent predictor of further damage (alarcon et al., 2004).
The role of thrombocytopenia as independent factor related to disease aggressiveness and outcome has been a mother of controversy leading to conflicting reports (Sultan et al., 2003).
In accordance with the most recent observation published it has been shown that although thrombocytopenia perse is a benign complication, it is associated with highly active disease and a worse outcome (Ziakas et al., 2006).