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العنوان
EVALUATION OF THE EFFECTS OF CALCIUM CHANNEL BLOCKERS ON CARBAMAZEPINE ADMINISTRATION/
الناشر
Ain Shams uni. Medicine. Clinical Toxicology
المؤلف
Halawa، Heba Mohamed
هيئة الاعداد
مشرف / El-Nayal، Naila Ahmed
مشرف / El-Sigini، Ahmed Ibrahim
مشرف / El-Taftazany ، Enas Abo El-Wafa
مشرف / Atalla، Suzy Sobhy
تاريخ النشر
2003
عدد الصفحات
170p.
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
الطب
تاريخ الإجازة
1/1/2003
مكان الإجازة
جامعة عين شمس - كلية الطب - Clinical Toxicology
الفهرس
Only 14 pages are availabe for public view

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Abstract

Carbamazepine is one of the most commonly prescribed antiepileptic and antipsychotic drugs. Its long term use makes it frequently prescribed in combination with other drugs. One of those drugs are the calcium channel blockers. This makes the possibility of drug interaction between them.
The aim of this study is to evaluate carbamazepine combined therapy with (diltiazem, verapamil and nifedipine and their effect on serum carbamazepine level, AST, ALT, Alkaline phosphatase, serum bilirubin, prothrombin time, serum Albumin, complete blood count, ECG changes and histopathological changes in the liver, heart and brain of rats receiving both drugs in therapeutic doses and for 2 periods of administration 2 and 4 weeks and to compare the degree of these interaction to know the least interacting calcium channel blockers