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Abstract
This study was carried out in the Medical Biochemistry andInternal Medicine departements, Faculty of Medicine, ZagazigUniversity. In this study, serum levels of IL-2, sIL-2R and TNF-awere determined in diabetic patients as a trial to through some lightand evaluate their possible role in the pathogenesis of diabetesmellitus.
This study comprised 44 subjects, they were classified into fourgroups:
Group I: Control group: This group included 10 apparentlyhealthy volunteers with no family history of diabetes or otherdiseases, which may interfere with the studied parameters.
Group II: Newly discovered type 1 diabetes: This groupcomprised 11 recently discovered diabetic patients, the knownduration of their disease was less than 3 months.
Group III: Type I diabetic patients: Twelve patients with long-standing type 1 diabetes were involved in this group. The knownduration of their disease was more than 2 years.
Group IV: Type 2 diabetic patients: Eleven patients with long-standing type 2 diabetes were involved in this group. The knownduration of their disease was more than 2 years.
All subjects were free from other diseases and not receivingany medications known to affect the studied parameters such as
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Summary and Conclosion
corticosteroids and immunosuppressive drugs and the diabeticpatients were selected according to WHO criteria.
Blood samples were collected and fasting and post-prandialplasma glucose, blood Hb A1c, serum IL-2, serum sIL-2R and TI\IF-ctwere determined and the results were statstically analyzed.
In this study, statistical analysis of fasting and post-prandialblood glucose revealed that their levels were significantly higher in alldiabetic groups as compared to control group. whereas, no significantdifference of fasting and post-prandial blood glucose was observedwhen the diabetic groups were compared with each other. There wasa significant positive correlation between fasting and post-prandialplasma glucose in all diabetic groups.