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Abstract
Background: Chronic hepatitis C infection and cirrhosis have slowly
progressive course and accompanied by liver inflammation and fibrosis.
Increased serum neopterin level has been detected in patients having
Chronic hepatitis C disease. Neopterin is produced by
monocytes/macrophages when activated by interferon-gamma secreted from
T lymphocytes as a part of body immune response against hepatitis C viral
infection.
Objectives: To assess the changes in the serum neopterin level in
Egyptian patients having chronic liver disease due to hepatitis C virus
infection and cirrhosis , and to correlate the neopterin levels with changes in
the laboratory parameters and pathological stages of liver disease .
Methods : 85 subjects were included; 40 patients having chronic hepatitis
C as group I , 30 patients having cirrhosis as group II and a control group
included 15 healthy subjects as group III .